Cart
sales@molnova.com
SOS1 activator 17
CAS No. 2228955-02-8
SOS1 activator 17( —— )
Catalog No. M13563 CAS No. 2228955-02-8
SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameSOS1 activator 17
-
NoteResearch use only, not for human use.
-
Brief DescriptionSOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM.
-
DescriptionSOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro; activates the nucleotide exchange process at submicromolar concentrations in vitro, increases levels of active RAS-GTP in HeLa cells, and elicits signaling changes in the MAPK-ERK pathway, resulting in a decrease in pERK1/2T202/Y204 protein levels.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayMAPK/ERK Signaling
-
TargetRas
-
RecptorRas
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2228955-02-8
-
Formula Weight496.436
-
Molecular FormulaC26H27Cl2N5O
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC1C2CN(CC2CN1CC3=CNC4=C3C=C(C=C4)Cl)C(=O)C(CC5=CNC6=C5C=CC(=C6)Cl)N
-
Chemical Name(2S)-2-Amino-3-(6-chloro-1H-indol-3-yl)-1-(5-((5-chloro-1H-indol-3-yl)methyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)propan-1-one
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Abbott JR, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.8b00360.
molnova catalog
related products
-
RAS inhibitor Abd-7
RAS inhibitor Abd-7 is a potent RAS-binding compound (Kd=51 nM) that interacts with RAS in cells.
-
ZCL278
A potent, cell-permeable Cdc42-specific small-molecule inhibitor (Kd=6.4 uM).
-
SAH-SOS1A
KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a concentration dependent manner. Displays cytotoxicity in KRas-driven cancer cell lines and inhibits downstream ERK-MAPK signaling. Cell permeable.
